HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8f92
Q-score: 0.516
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) [ DOI: doi:10.1126/science.adk0582 ]
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- B11_d77.7 fab heavy chain (14 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 env bg505_md39_b11 sosip in complex with fabs b11_d77.7 and rm20a3 (Complex)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- B11_d77.7 fab kappa light chain (11 kDa, Protein from Mus musculus)
- Bg505_md39_b11 gp120 (54 kDa, Protein from Human immunodeficiency virus)
- Bg505_md39_b11 gp41 (18 kDa, Protein from Human immunodeficiency virus)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8f9g
Q-score: 0.446
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) [ DOI: doi:10.1126/science.adk0582 ]
- V3-glycan epitope polyclonal fab heavy chain (10 kDa, Protein from Mus musculus)
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized bg18hcgl knock-in mice v3-glycan epitope polyclonal fab heavy chain (Complex from Mus musculus)
- V3-glycan epitope polyclonal fab light chain (8 kDa, Protein from Mus musculus)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8f9m
Q-score: 0.346
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) [ DOI: doi:10.1126/science.adk0582 ]
- Bg505_md64_n332-gt5 gp41 (18 kDa, Protein from synthetic construct)
- Bg505_md64_n332-gt5 gp120 (54 kDa, Protein from synthetic construct)
- V3-glycan epitope polyclonal fab heavy chain (9 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V3-glycan epitope polyclonal fab light chain (9 kDa, Protein from Mus musculus)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv env germline targeting bg505_md64_n332-gt5 sosip in complex with v3-glycan polyclonal fab isolated from immunized wild type mice, and nhp monoclonal fab rm20a3 (Complex from Mus musculus)
HIV Env BG505_MD39_B16 SOSIP boosting trimer in complex with B16_d77.5 mouse Fab and RM20A3 Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vfv
Q-score: 0.495
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD
Science (2024) [ DOI: doi:10.1126/science.adk0582 ]
- B16_d77.5 mouse fab heavy chain fv (13 kDa, Protein from Mus musculus)
- Iv env bg505_md39_b16 sosip boosting trimer in complex with b16_d77.5 mouse fab and rm20a3 fab (Complex from Human immunodeficiency virus 1)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- B16_d77.5 mouse fab light chain fv (12 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab
Science (2024) [ DOI: doi:10.1126/science.adj8321 ]
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Rm_n332_03 heavy chain fv (14 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip in complex with rm_n332_03 fab and rm20a3 fab (Complex from Macaca mulatta)
- Rm_n332_03 light chain fv (11 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab
Science (2024) [ DOI: doi:10.1126/science.adj8321 ]
- Rm_n332_36 heavy chain fv (14 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip in complex with rm_n332_36 fab and rm20a3 fab (Complex from Macaca mulatta)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Rm_n332_36 light chain fv (11 kDa, Protein from Macaca mulatta)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
MD65 N332-GT5 SOSIP in complex with RM_N332_32 Fab and RM20A3
Science (2024) [ DOI: doi:10.1126/science.adj8321 ]
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Rm_n332_32 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Rm_n332_32 light chain fv (11 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Md65 n332-gt5 sosip in complex with rm_n332_32 fab and rm20a3 fab (Complex from Macaca mulatta)
MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab
Science (2024) [ DOI: doi:10.1126/science.adj8321 ]
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip in complex with rm_n332_08 fab and rm20a3 fab (Complex from Macaca mulatta)
- Rm_n332_08 light chain fv (12 kDa, Protein from Macaca mulatta)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Rm_n332_08 heavy chain fv (14 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Science (2024) [ DOI: doi:10.1126/science.adj8321 ]
- Md64 n332-gt5 sosip gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Md64 n332-gt5 sosip (Complex from Human immunodeficiency virus 1)
- Md64 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
MD65 N332-GT5 SOSIP in complex with RM_N332_07 Fab and RM20A3 Fab
Science (2024) [ DOI: doi:10.1126/science.adj8321 ]
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm_n332_07 light chain fv (11 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Rm_n332_07 heavy chain fv (14 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip in complex with rm_n332_07 fab and rm20a3 fab (Complex from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)